Chronic Inflammatory Activation

Gene co-expression module in Endothelial

View this module in SCUBA

Why this annotation

FOSL2 (Fra-2) is an AP-1 transcription factor associated with chronic inflammatory activation and is upregulated in IBD endothelium. LMNA encodes Lamin A/C, a nuclear lamina protein involved in mechanosensing and inflammatory NF-κB signaling; mutations cause inflammatory vasculopathies. ABL2 is a non-receptor tyrosine kinase activated by inflammatory cytokines and involved in cytoskeletal remodeling. EMP1 is upregulated in inflammatory conditions. HRH1 encodes the histamine H1 receptor, mediating vascular permeability in inflammation. ADAMTS9 is an ECM-remodeling metalloprotease upregulated in inflammatory angiogenesis. PNP (purine nucleoside phosphorylase) participates in purine metabolism relevant to inflammatory signaling. DDX21 is an RNA helicase involved in ribosome biogenesis and stress responses. SLC20A1 is a phosphate transporter induced by growth factors. VMP1 is involved in autophagy. The module is significantly upregulated in both UC and CD inflammation with no remission recovery, suggesting chronic inflammatory endothelial activation. As a neighbor to M63 and M111, this module represents a complementary chronic inflammatory program, distinguished by FOSL2-driven AP-1 activity and ECM remodeling.

Genes

ABL2, ADAMTS9, DDX21, EMP1, FOSL2, HRH1, KRT10, LMNA, PNP, SLC20A1, VMP1

Most correlated modules

• Inflammatory Stress Response · correlation 0.80
• Stress RNA Processing · correlation 0.69
• Endothelial Quiescence · correlation 0.67
• NF-κB Early Response · correlation 0.65
• Notch Arterial Identity · correlation 0.56

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.