Stress RNA Processing
Gene co-expression module in Endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
The top hub genes RBM8A (exon junction complex component), HNRNPF, PTBP1, HNRNPDL, and EWSR1 are all RNA-binding proteins involved in mRNA splicing and post-transcriptional regulation. ELOC (elongin C) participates in transcription elongation and ubiquitin E3 ligase complexes. CACYBP and ZFAND5 are ubiquitin-pathway components. ENY2 is involved in transcription and deubiquitination. ARF4 mediates vesicle trafficking. XBP1 is the master UPR transcription factor, linking this module to ER stress. MAP3K13 is a stress-activated kinase. The module is upregulated in both UC and CD inflammation. The combination of hnRNP splicing factors with XBP1 suggests stress-induced alternative splicing and UPR-coupled RNA processing.
Genes
ARF4, CACYBP, ELOC, ENY2, EWSR1, GNA14, HNRNPDL, HNRNPF, MAP3K13, PTBP1, RBM8A, SERPINB1, XBP1, ZFAND5
Most correlated modules
- Inflammatory Stress Response · correlation 0.85
- NF-κB Endothelial Activation · correlation 0.82
- Endothelial Quiescence · correlation 0.80
- Wnt Angiogenic Remodeling · correlation 0.80
- Spliceosome snRNP Assembly · correlation 0.78
- mRNA Splicing · correlation 0.74
- NF-κB Early Response · correlation 0.73
- Chronic Inflammatory Activation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.