Inflammatory Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Top hub TNFAIP1 is a TNF-alpha-induced gene. SERPINH1 (HSP47) is an ER-resident collagen chaperone induced by ER stress and inflammation. GCLM encodes the regulatory subunit of glutamate-cysteine ligase, a key oxidative stress response enzyme. STC2 is an ER stress and hypoxia-induced secreted protein. ODC1 is induced by inflammatory signals and drives polyamine synthesis. SLC1A5 is an amino acid transporter upregulated under metabolic stress. KRAS, CRK, DLC1, TLNRD1, TES are signaling/cytoskeletal genes. SKIL is a TGF-β pathway inhibitor. The module is significantly upregulated in both UC and CD inflammation with no treatment or remission response, suggesting a sustained inflammatory stress activation program. The combination of TNF-response, oxidative stress (GCLM), and ER stress (SERPINH1, STC2, SERP1) defines an integrated stress response.
Genes
CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1, SERPINH1, SKIL, SLC1A5, STC2, TES, TLNRD1, TNFAIP1, UTP11
Most correlated modules
- Stress RNA Processing · correlation 0.85
- Endothelial Quiescence · correlation 0.81
- Chronic Inflammatory Activation · correlation 0.80
- NF-κB Early Response · correlation 0.72
- Wnt Angiogenic Remodeling · correlation 0.65
- VEGF Tip Cell Signaling · correlation 0.64
- Heat Shock Response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.