NF-κB Early Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes BHLHE40, KLF10, TRIB1, BCL3, and SNAI1 are all transcription factors activated by inflammatory, hypoxic, or NF-κB signals. ICAM1 is a canonical endothelial activation marker. INSIG1 and LDLR reflect lipid-metabolic co-regulation. The module is strongly associated with UC remission (delta_remission_UC=0.365), suggesting a homeostatic endothelial transcriptional program suppressed during active inflammation. BCL3 and TRIB1 are known NF-κB modulators; BHLHE40 and KLF10 are early-response TFs. Together these represent an NF-κB-modulated early transcriptional response in endothelial cells.
Genes
BCL3, BHLHE40, ICAM1, INSIG1, ITPKC, KLF10, LDLR, MYADM, RND1, SLC25A25, SNAI1, TRIB1
Most correlated modules
- Heat Shock Response · correlation 0.90
- Integrated Stress Response · correlation 0.84
- NF-κB Activation · correlation 0.82
- Endothelial Quiescence · correlation 0.79
- Shear Stress Response · correlation 0.78
- Inflammatory Angiogenesis · correlation 0.77
- Notch Ligand Signaling · correlation 0.74
- Stress RNA Processing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.