S-phase DNA Replication
Gene co-expression module in Endothelial
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
All 9 genes are core S-phase DNA replication and replication-coupled repair factors: PCNA and RFC4 (replication clamp/loader), MCM7 (replication licensing helicase), LIG1 (replication fork ligation), CHEK1 (S-phase checkpoint kinase), HELLS (replication-associated chromatin remodeler), FANCA (replication-coupled DNA repair), DNAJC9 (histone chaperone at replication forks), WDR76 (DNA damage/replication stress response). The module is strongly upregulated in active UC and CD inflammation and reverses in remission, consistent with inflammation-driven endothelial proliferation. Neighbor M112 represents M-phase, confirming this is the complementary S-phase arm of the cell cycle program.
Genes
CHEK1, DNAJC9, FANCA, HELLS, LIG1, MCM7, PCNA, RFC4, WDR76
Most correlated modules
- S-phase Proliferation · correlation 0.93
- DNA Replication · correlation 0.88
- Mitotic Cell Cycle · correlation 0.82
- Nuclear Transport · correlation 0.78
- Mitotic Spindle · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.