PCNA — Proliferating cell nuclear antigen
PCNA belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCNA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | CDC45, CENPH, DHFR, FEN1, GINS2, MCM3, MCM5, MCM7 +3 more | View in SCUBA |
| CD8⁺ T cells | DNA Replication Fork Cell cycle | CDC6, CDT1, CHAF1A, CTNNAL1, DHFR, DUT, FEN1, LIG1 +5 more | View in SCUBA |
| Endothelial | S-phase DNA Replication Cell cycle | CHEK1, DNAJC9, FANCA, HELLS, LIG1, MCM7, RFC4, WDR76 | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Goblet cells | MCM Replication Licensing Cell cycle | CDT1, DNMT1, DUT, FAM111B, GINS2, HELLS, MCM3, MCM4 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN +4 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | DNA Replication Cell cycle | ATAD2, DHFR, FEN1, LIG1, MCM7, TK1, TMEM106C, UHRF1 | View in SCUBA |
About the gene
| Chromosome | 20: 5114953-5126626 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA damage, DNA repair, DNA replication, Host-virus interaction |
Function
Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.