Mitotic Spindle
Gene co-expression module in Endothelial
| Category | Cell cycle |
|---|---|
| Genes | 23 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 23 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical mitotic spindle and M-phase genes: TPX2, NUSAP1, CKAP2, TACC3, ASPM (spindle assembly/organization); NDC80, CENPE, SGO2, CENPF, MAD2L1 (kinetochore and spindle assembly checkpoint); CDK1, CCNB1 (mitotic kinase/cyclin); UBE2C, UBE2T (APC/C-mediated mitotic exit ubiquitination); RACGAP1, KIF20B (cytokinesis); TOP2A (chromosome segregation); MKI67 (mitosis marker); LMNB1 (nuclear lamina remodeling in mitosis); PHF19 (PRC2-associated, mitotic chromatin). All 20 listed genes are core mitotic machinery. Strong upregulation in UC/CD inflammation with remission reversal mirrors M137, confirming a shared proliferative program in inflamed endothelium. Neighbor M137 represents S-phase, making this the M-phase complement.
Genes
ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN, LMNB1, MAD2L1, MKI67, MXD3, NCAPD2, NDC80, NUSAP1, PHF19, RACGAP1, SGO2, TACC3, TOP2A, TPX2, UBE2C, UBE2T
Most correlated modules
- Mitotic Cell Cycle · correlation 0.98
- S-phase Proliferation · correlation 0.92
- Nuclear Transport · correlation 0.77
- S-phase DNA Replication · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.