RFC4 — Replication factor C subunit 4
RFC4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RFC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | CDC45, CENPH, DHFR, FEN1, GINS2, MCM3, MCM5, MCM7 +3 more | View in SCUBA |
| CD8⁺ T cells | DNA Replication Fork Cell cycle | CDC6, CDT1, CHAF1A, CTNNAL1, DHFR, DUT, FEN1, LIG1 +5 more | View in SCUBA |
| Endothelial | S-phase DNA Replication Cell cycle | CHEK1, DNAJC9, FANCA, HELLS, LIG1, MCM7, PCNA, WDR76 | View in SCUBA |
| Gamma-delta T cells | DNA Replication Licensing Cell cycle | BRCA1, CHAF1A, HELLS, MCM2, MCM3, MCM4, MCM5, MCM7 +2 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | A1, RFC37 |
|---|---|
| Chromosome | 3: 186789880-186807058 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | DNA replication |
Function
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.