Mitotic Cell Cycle
Gene co-expression module in Endothelial
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical cell-cycle/mitosis markers: CKS1B (CDK regulatory subunit, S/G2/M), CENPW and CENPN (centromere proteins, kinetochore assembly), BIRC5 (survivin, chromosomal passenger complex), PTTG1 (securin, anaphase regulation), DTYMK (thymidylate kinase, dNTP synthesis), SMC2 and SMC4 (condensin complex), PRR11 (G2/M regulator), ANP32E (histone chaperone/chromatin), TMPO (lamina-associated, mitosis). GGH (gamma-glutamyl hydrolase, folate metabolism supporting nucleotide synthesis). The module is extremely tightly co-regulated (all core membership), very low baseline expression (12% positive), and shows the strongest inflammation upregulation in the batch (delta_UC=0.736, delta_CD=0.504) with near-complete reversal in remission (delta_remission_UC=-0.763). This pattern reflects proliferating endothelial cells in inflamed tissue. The module is a clean mitotic cell-cycle program.
Genes
ANP32E, BIRC5, CENPN, CENPW, CKS1B, DTYMK, GGH, PRR11, PTTG1, SMC2, SMC4, TMPO
Most correlated modules
- Mitotic Spindle · correlation 0.98
- S-phase Proliferation · correlation 0.96
- Nuclear Transport · correlation 0.83
- S-phase DNA Replication · correlation 0.82
- DNA Replication · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.