S-phase Proliferation
Gene co-expression module in Endothelial
| Category | Cell cycle |
|---|---|
| Genes | 20 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 20 genes have a known function matching the annotation |
Why this annotation
This module has the highest inflammation delta in the entire batch (UC=0.900, CD=0.671) and the strongest remission reversal (UC=-0.846), with very low baseline expression (3.6% positive), indicating a tightly regulated proliferative program activated specifically in inflamed tissue. Hub genes: PCLAF (PCNA-associated factor, S-phase), CENPU/CENPK/CENPH (kinetochore/centromere proteins), FANCI (Fanconi anemia DNA repair), TYMS (thymidylate synthase, dNTP synthesis), ZWINT (kinetochore), BRCA2/BRCA1 (homologous recombination DNA repair), ATAD2 (chromatin remodeling, proliferation), DHFR (dihydrofolate reductase, nucleotide synthesis), TK1 (thymidine kinase, S-phase marker), TCF19 (transcription factor, cell proliferation), EZH2 (PRC2 methyltransferase, proliferation), NCAPG2/NCAPD3 (condensin II, mitosis), FEN1 (DNA replication/repair), ATAD5 (PCNA unloading), ORC6 (origin recognition complex), RRM1 (ribonucleotide reductase). This is a canonical S-phase/G2 DNA replication and repair module, the most proliferation-specific in the batch.
Genes
ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR, EZH2, FANCI, FEN1, NCAPD3, NCAPG2, ORC6, PCLAF, RRM1, TCF19, TK1, TYMS, ZWINT
Most correlated modules
- Mitotic Cell Cycle · correlation 0.96
- S-phase DNA Replication · correlation 0.93
- Mitotic Spindle · correlation 0.92
- DNA Replication · correlation 0.81
- Nuclear Transport · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.