DNA Replication
Gene co-expression module in Endothelial
| Category | Cell cycle |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
MCM3, MCM4, MCM5, MCM6 are minichromosome maintenance helicase subunits essential for DNA replication licensing and S-phase entry. RPA3 is a replication protein A subunit. POLD2 is DNA polymerase delta subunit 2. DNMT1 is the maintenance DNA methyltransferase (replication-coupled). SLBP is the stem-loop binding protein for histone mRNA (S-phase specific). CENPX is a centromere protein. RABL6 is a cell-cycle regulator. IDH2 is a mitochondrial isocitrate dehydrogenase. ICMT is an isoprenylcysteine carboxyl methyltransferase. SIVA1 is a pro-apoptotic protein. The dominant signal is DNA replication (MCM3/4/5/6, RPA3, POLD2, DNMT1, SLBP). Upregulated in inflammation, reversed in remission. Neighbor context: adjacent to M96 (mitotic cycle) and M141 (S-phase/DNA repair), forming a coherent proliferation neighborhood. This module specifically captures S-phase DNA replication.
Genes
CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6, NR2C2AP, NT5DC2, PGP, POLD2, RABL6, RPA3, SIVA1, SLBP, TECR, TMEM160, TMX4, YIF1B
Most correlated modules
- Nuclear Transport · correlation 0.89
- S-phase DNA Replication · correlation 0.88
- DNA Damage Repair · correlation 0.85
- Nuclear Transport · correlation 0.84
- S-phase Proliferation · correlation 0.81
- Mitotic Cell Cycle · correlation 0.77
- mRNA Splicing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.