Capillary Endothelial Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include RBP7 (retinol binding protein 7, a marker of capillary/adipose tissue endothelium), CD34 (endothelial progenitor and capillary marker), MEF2C (MADS-box transcription factor critical for endothelial identity and angiogenesis), RCAN2 (regulator of calcineurin, downstream of VEGF signaling in endothelium), ATOH8 (bHLH transcription factor expressed in endothelium), CD300LG (endothelial lipid receptor), AVPR2 (vasopressin V2 receptor, expressed in vascular endothelium), LIPE (hormone-sensitive lipase), and BTNL9 (butyrophilin-like). RBP7 is particularly notable as a capillary endothelial marker. The module is significantly decreased during inflammation (UC -0.411, CD -0.259) and recovers in remission, consistent with homeostatic microvascular/capillary endothelial identity suppressed during IBD. Neighbor M25 has venous identity genes; M26 appears to represent a complementary capillary/microvascular endothelial program.
Genes
ATOH8, AVPR2, BTNL9, C1QTNF9, CD300LG, CD34, CNFN, FAM13C, IQCK, KNOP1, LIPE, LPAR6, MEF2C, OLFML2A, RBP7, RCAN2, SEMA6C, TCF15, TMEM88
Most correlated modules
- Venous Endothelial Identity · correlation 0.86
- Endothelial Lipid Signaling · correlation 0.84
- Glucocorticoid Response · correlation 0.74
- Caveolae-mediated Transcytosis · correlation 0.74
- Angiogenic Endothelial Identity · correlation 0.70
- Venous Endothelial Identity · correlation 0.70
- Glucocorticoid Response · correlation 0.69
- IL-27 Receptor Signaling · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.