Arterial EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
ACVRL1 (ALK1) and ENG (endoglin) are the two defining receptors of the BMP9/TGF-β signaling axis that specifies arterial endothelial identity; mutations in both cause hereditary hemorrhagic telangiectasia. PLXND1 is a semaphorin receptor required for arterial identity and patterning. PROS1 (protein S) is an anticoagulant produced by arterial endothelium. LDB2 is a transcriptional co-factor enriched in arterial ECs. SLCO2A1 transports prostaglandins and is expressed in vascular endothelium. The module shows minimal disease response, consistent with a stable cell-identity program rather than an inflammatory response. As a neighbor to M77 (angiogenic), this module refines the endothelial subtype to arterial specification.
Genes
ACVRL1, ANXA11, ATP13A2, ENG, HPCAL1, HYAL1, LDB2, MACF1, NFIB, PCGF2, PLXND1, PROS1, RBMS2, SLCO2A1, SNRK, TMEM181
Most correlated modules
- Venous Endothelial Identity · correlation 0.86
- IL-27 Receptor Signaling · correlation 0.83
- Endothelial Lipid Signaling · correlation 0.80
- Integrin-Actin Adhesion · correlation 0.79
- Mitophagy Stress Response · correlation 0.79
- Angiogenic Endothelial Identity · correlation 0.77
- Basement Membrane Assembly · correlation 0.75
- Vascular Barrier Integrity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.