Notch Ligand Signaling
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
DLL1 is a canonical Notch ligand expressed on endothelial cells (tip/stalk cell signaling). ITM2A is associated with Notch signaling and endothelial differentiation. LTBR (lymphotoxin-β receptor) activates non-canonical NF-κB and is expressed on endothelial cells in lymphoid tissue contexts. MLKL is the necroptosis executor kinase. SLC2A3 (GLUT3) reflects metabolic adaptation. ZC3HAV1 is an antiviral RNA helicase. TRA2B is an SR splicing factor. ZNF436 is a zinc finger TF. The remission association (delta_remission_UC=0.188) and the DLL1/ITM2A Notch axis suggest this module reflects endothelial Notch-mediated cell fate signaling, possibly in the context of vascular remodeling during mucosal healing.
Genes
DLL1, ITM2A, KRT222, LTBR, MLKL, SLC2A3, TRA2B, ZC3HAV1, ZNF436
Most correlated modules
- Heat Shock Response · correlation 0.79
- Endothelial Quiescence · correlation 0.76
- NF-κB Early Response · correlation 0.74
- Shear Stress Response · correlation 0.70
- Integrated Stress Response · correlation 0.67
- Glucocorticoid Response · correlation 0.59
- Vasoactive GPCR Signaling · correlation 0.59
- NF-κB Activation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.