NF-κB Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
This module is a canonical NF-κB activation program. TNFAIP3 (A20) and NFKBIA (IκBα) and NFKBID (IκBNS) are all NF-κB negative feedback regulators that are themselves NF-κB target genes. SQSTM1 (p62) links NF-κB to autophagy. PTGS2 (COX-2) is a classic NF-κB inflammatory target. IER3 and MAP3K8 (TPL2) are inflammatory kinase/immediate-early components. TIFA activates TRAF6/NF-κB. TNFSF9 (4-1BBL) is an NF-κB target. SOD2 is an NF-κB-regulated antioxidant. PMAIP1 (NOXA) links to apoptotic stress. HSPA6 is a stress chaperone. The module is significantly upregulated in CD inflammation. Neighbor to M109 (HSP stress) and M113 (ATF3/DDIT3 stress TFs), forming a coherent inflammatory-stress neighborhood.
Genes
C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, NFKBID, PMAIP1, PTGS2, SOD2, SQSTM1, TIFA, TNFAIP3, TNFSF9
Most correlated modules
- NF-κB Early Response · correlation 0.82
- Integrated Stress Response · correlation 0.82
- Inflammatory Angiogenesis · correlation 0.80
- Heat Shock Response · correlation 0.78
- Endothelial Chemokine Response · correlation 0.77
- NF-κB Endothelial Activation · correlation 0.76
- Stress RNA Processing · correlation 0.68
- Endothelial Quiescence · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.