Heat Shock Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical heat shock proteins: HSPH1 (HSP110), HSPA8 (HSC70), HSPD1 (HSP60), HSPE1 (HSP10), DNAJA1 and DNAJA4 (HSP40 co-chaperones), and BAG3 (chaperone-assisted selective autophagy co-chaperone). PPP1R15A (GADD34) is a key integrated stress response phosphatase that dephosphorylates eIF2α. IER5 is an immediate-early stress gene. TNFRSF10D is a decoy TRAIL receptor upregulated under stress. All genes are core members with high mean expression and detection rate. The remission association (delta_remission_UC=0.299) suggests this proteostatic program is restored as inflammation resolves. Neighbor modules M107 (NF-κB) and M113 (ATF3/DDIT3) confirm a stress response neighborhood.
Genes
BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5, MRPL18, PPP1R15A, TNFRSF10D
Most correlated modules
- Integrated Stress Response · correlation 0.95
- Shear Stress Response · correlation 0.91
- NF-κB Early Response · correlation 0.90
- Notch Ligand Signaling · correlation 0.79
- NF-κB Activation · correlation 0.78
- Inflammatory Angiogenesis · correlation 0.70
- Stress RNA Processing · correlation 0.67
- Endothelial Quiescence · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.