Integrated Stress Response

Gene co-expression module in Endothelial

View this module in SCUBA

Why this annotation

MAFF (small Maf), ATF3, and DDIT3 (CHOP) are all integrated stress response (ISR) and UPR transcription factors activated downstream of eIF2α phosphorylation. NFKBIZ (IκBζ) is an atypical IκB that modulates NF-κB in inflammatory contexts. IRF1 is an interferon-regulatory factor activated by inflammatory cytokines. CD83 is an activation-induced surface marker. KDM6B (JMJD3) is an H3K27 demethylase that epigenetically activates inflammatory gene programs. CDKN1A (p21) mediates stress-induced cell cycle arrest. CCNL1 is a cyclin involved in splicing regulation. The very strong delta_remission_UC=0.423 suggests this program is suppressed during active inflammation and restored at remission. Together, MAFF/ATF3/DDIT3 define an integrated stress response transcription factor module with inflammatory co-activation.

Genes

ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1, KDM6B, MAFF, NFKBIZ, TSPYL2

Most correlated modules

• Heat Shock Response · correlation 0.95
• Shear Stress Response · correlation 0.89
• NF-κB Early Response · correlation 0.84
• NF-κB Activation · correlation 0.82
• Inflammatory Angiogenesis · correlation 0.74
• Endothelial Chemokine Response · correlation 0.73
• Notch Ligand Signaling · correlation 0.67
• Notch Arterial Identity · correlation 0.59

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.