Glucocorticoid Response
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes SGK1, TSC22D1, KLF9, KLF11, PHLPP1, and NDRG1 are all canonical glucocorticoid-responsive or PI3K-AKT pathway regulators. THBD and JAM3 support endothelial barrier/quiescence. The module is suppressed in inflammation and elevated in UC remission, consistent with a glucocorticoid-responsive quiescent endothelial program that is restored upon disease resolution.
Genes
APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1, PHLPP1, PITPNM2, SDE2, SGK1, STIM2, TCIM, THBD, TSC22D1, VPS37B
Most correlated modules
- Glucocorticoid Response · correlation 0.88
- Venous Endothelial Identity · correlation 0.77
- Venous Endothelial Identity · correlation 0.74
- Capillary Endothelial Identity · correlation 0.74
- Endothelial Lipid Signaling · correlation 0.73
- Caveolae-mediated Transcytosis · correlation 0.66
- Venous EC Identity · correlation 0.65
- IL-27 Receptor Signaling · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.