Chromatin Cell Cycle
Gene co-expression module in Endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
ARPP19 (cAMP-regulated phosphoprotein 19) is a potent inhibitor of PP2A phosphatase and a known regulator of mitotic entry and cell cycle progression. PDS5B is a cohesin-associated factor required for sister chromatid cohesion. BRD7 is a chromatin remodeling factor (SWI/SNF complex). MBD2 is a methyl-CpG binding domain protein involved in epigenetic regulation. IPO9 (importin-9) mediates nuclear import of actin and other cargo. CMPK1 is a nucleotide kinase supporting DNA/RNA synthesis. CCPG1 is an ER-phagy receptor. TM9SF2 is a lysosomal membrane protein. The module is small and mixed, but the chromatin/cell cycle theme (ARPP19, PDS5B, BRD7, MBD2) is the most coherent biological program. Mild inflammation upregulation.
Genes
ARPP19, BRD7, CCPG1, CMPK1, IPO9, MBD2, PDS5B, TM9SF2
Most correlated modules
- WAVE Complex Cytoskeleton · correlation 0.92
- Integrin-Actin Adhesion · correlation 0.84
- Endothelial Angiogenic Identity · correlation 0.84
- Rho-Actin Remodeling · correlation 0.83
- ER-Golgi Trafficking · correlation 0.83
- DNA Damage Repair · correlation 0.81
- Cytoskeletal Scaffolding · correlation 0.79
- Endocytic Membrane Remodeling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.