DNA Damage Repair
Gene co-expression module in Endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Top hubs PRKDC (DNA-PKcs) and XRCC6 (Ku70) are core components of the non-homologous end joining (NHEJ) DNA repair pathway. SMC3 is a cohesin subunit involved in DNA repair and chromosome cohesion. SET is a histone chaperone/PP2A inhibitor. HNRNPR and HNRNPM are RNA-binding proteins. TPR is a nuclear pore component. NAP1L4 is a nucleosome assembly protein. HMGB1 is a chromatin/DAMP protein. NCL (nucleolin) is a nucleolar protein. USP1 is a deubiquitinase involved in DNA damage response. APPL1 is an endosomal adaptor. GPAA1 is a GPI transamidase. VMA21 is a V-ATPase assembly factor. TPGS2 is a tubulin glutamylase. PRDX3 is a mitochondrial peroxiredoxin. The dominant signal is DNA repair/damage response (PRKDC, XRCC6, SMC3, USP1, HMGB1, NAP1L4, SET). Mild upregulation in inflammation. Neighbor context: adjacent to cell-cycle and chromatin modules, consistent with DNA damage response in proliferating cells.
Genes
APPL1, GPAA1, HMGB1, HNRNPM, HNRNPR, NAP1L4, NCL, PRDX3, PRKDC, SET, SMC3, TPGS2, TPR, USP1, VMA21, XRCC6
Most correlated modules
- Nuclear Transport · correlation 0.87
- Rho-Actin Remodeling · correlation 0.85
- DNA Replication · correlation 0.85
- ER-Golgi Trafficking · correlation 0.84
- Actin Cytoskeletal Remodeling · correlation 0.83
- Chromatin Cell Cycle · correlation 0.81
- ER-Golgi Trafficking · correlation 0.80
- mRNA Splicing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.