Endocytic Membrane Remodeling
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub gene EIF4G2 (translation initiation) and PICALM (clathrin-mediated endocytosis) suggest a program of translational regulation and vesicle trafficking. PTPN12 (PTP-PEST) regulates focal adhesion turnover. LRRC8A is the essential subunit of the volume-regulated anion channel (VRAC), activated by cell swelling/osmotic stress. ARHGAP23 and BNIP2 regulate Rho GTPase signaling. LPCAT1 remodels membrane phospholipids. CDK17 is a non-canonical CDK involved in endocytosis. Upregulation in UC and CD inflammation suggests this program is activated during inflammatory endothelial stress. The dominant theme is clathrin-mediated endocytosis and membrane remodeling, potentially linked to receptor internalization during inflammation.
Genes
ARHGAP23, BNIP2, CDK17, EIF4G2, HERC1, KCTD15, LPCAT1, LRRC8A, LUZP1, PICALM, PTPN12, SKI, WWC2
Most correlated modules
- Inflammatory Kinase Signaling · correlation 0.88
- WAVE Complex Cytoskeleton · correlation 0.88
- Endothelial Junction Identity · correlation 0.86
- Vascular Tone Regulation · correlation 0.85
- Endothelial Angiogenic Identity · correlation 0.84
- Integrin-Actin Adhesion · correlation 0.82
- Inflammatory Angiogenic Activation · correlation 0.79
- Actomyosin Contractility · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.