Rho-Actin Remodeling
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
ARPC2 and ARPC5 (Arp2/3 complex subunits) are top hub genes driving actin filament branching, directly linking this module to M106 (ARPC5L) in the actin remodeling neighborhood. RHOA, HRAS, RAP1A, and GNAI2 are small GTPases that regulate actin dynamics and cytoskeletal organization downstream of inflammatory signals. KIF5B (kinesin-1) and RAB2A coordinate cytoskeletal-dependent vesicle transport. PSMB6, PSMD4, PSMD8, and PSMD13 are proteasome subunits co-expressed with the cytoskeletal program, likely reflecting coupled protein turnover. ANAPC11 (APC/C) and PPP1CA add cell cycle/phosphatase regulation. SRP9 is a signal recognition particle component. The module represents Rho/Arp2/3-driven actin remodeling with proteasomal co-regulation.
Genes
ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B, PDAP1, PPP1CA, PSMB6, PSMD13, PSMD4, PSMD8, RAB2A, RAP1A, RHOA, SRP9
Most correlated modules
- ER Calcium Stress · correlation 0.91
- Inflammatory Lipid Metabolism · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.87
- mRNA Splicing Stress · correlation 0.85
- Actin Vesicle Trafficking · correlation 0.85
- DNA Damage Repair · correlation 0.85
- Hippo-YAP Cytoskeletal · correlation 0.85
- Endothelial NO Activation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.