Cytoskeletal Scaffolding
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Top hub genes are UTRN (utrophin, links actin cytoskeleton to membrane), SPTAN1 (spectrin alpha, cortical cytoskeleton), MAP4 (microtubule-associated protein), ADD1 (adducin, actin-spectrin crosslinker), DOCK1 (Rac1 GEF, actin remodeling), CDC42BPA (MRCK, actomyosin). The module is dominated by spectrin/actin network and microtubule organization components, consistent with cytoskeletal scaffolding. ANO6 (phospholipid scramblase linked to cytoskeletal anchoring) and ARL6IP5 also fit. Mild upregulation in inflammation may reflect cytoskeletal remodeling during EC activation.
Genes
ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, DOCK1, ERC1, MAP4, NPTN, PCMTD1, SMARCA2, SPTAN1, UBE2Q2, UTRN
Most correlated modules
- EC Quiescence Identity · correlation 0.90
- EC Inflammatory Activation · correlation 0.90
- WAVE Complex Cytoskeleton · correlation 0.90
- Vascular Homeostasis · correlation 0.88
- Arterial EC Identity · correlation 0.86
- EC Barrier Integrity · correlation 0.86
- Inflammatory Angiogenic Activation · correlation 0.81
- Endothelial Junction Identity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.