Endothelial Angiogenic Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes PECAM1 (CD31), ESAM, CD93, ADGRL4 (ELTD1), CLEC14A are canonical endothelial markers and angiogenic regulators. CLIC4 is required for TGFβ-driven angiogenesis. MYH9 and ACTN4 provide cytoskeletal support for endothelial morphology. TGFBR1 and CAVIN1 (caveolae) are endothelial signaling components. PRKAA1 (AMPK) regulates endothelial metabolism. This is the most canonical endothelial identity/angiogenesis module in the batch, with tight coherence across all core members.
Genes
ACTN4, ADGRL4, APBB2, CAVIN1, CD93, CLEC14A, CLIC4, ESAM, MYH9, PECAM1, PLEC, PRKAA1, TACC2, TGFBR1
Most correlated modules
- WAVE Complex Cytoskeleton · correlation 0.90
- Integrin-Actin Adhesion · correlation 0.89
- Endothelial Junction Identity · correlation 0.88
- Endocytic Membrane Remodeling · correlation 0.84
- Chromatin Cell Cycle · correlation 0.84
- Hypoxia-IFN Endothelial · correlation 0.84
- Mitophagy Stress Response · correlation 0.83
- Endothelial Lipid Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.