Hypoxia Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
BAALC (brain and acute leukemia cytoplasmic) is expressed in hematopoietic progenitors and some ECs. EGLN3 (PHD3) is a prolyl hydroxylase that regulates HIF under hypoxia, marking hypoxic/arterial ECs. ALDH2 is involved in aldehyde detoxification. CIRBP is a cold/stress-inducible RNA-binding protein. PAWR is a pro-apoptotic factor. MEIS2 is a TALE homeobox TF. EPB41 (band 4.1) is a cytoskeletal linker. FTL (ferritin light chain) reflects iron/oxidative stress. ABCA5 is an ABC transporter. The module is significantly decreased in UC inflammation and shows a mixed arterial EC identity with stress/hypoxia response elements. EGLN3 and CIRBP together suggest a hypoxia-sensing program.
Genes
ABCA5, ALDH2, BAALC, CIRBP, EGLN3, EPB41, FARP1, FTL, LRP5, MEGF6, MEIS2, PAWR, PDLIM3, PNRC1, SAMD12, ZMAT3
Most correlated modules
- Venous EC Identity · correlation 0.81
- Arterial EC Identity · correlation 0.81
- Inflammatory ECM Remodeling · correlation 0.76
- Quiescent Arterial EC · correlation 0.71
- Venous EC Identity · correlation 0.71
- Macrophage Contamination · correlation 0.70
- Quiescent EC Identity · correlation 0.64
- NF-κB Stress Signaling · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.