Endothelial Chemokine Response
Gene co-expression module in Endothelial
| Category | Chemotaxis |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 23 genes have a known function matching the annotation |
Why this annotation
This module is dominated by canonical endothelial inflammatory activation genes: CXCL1, CXCL2, CXCL3 (neutrophil-recruiting ELR+ CXC chemokines), CCL2 (monocyte chemoattractant), CEBPB and CEBPD (master acute-phase/inflammatory C/EBP transcription factors), REL (NF-κB c-Rel subunit), and IRF8 (interferon regulatory factor). LRG1 is an endothelial-specific pro-angiogenic factor upregulated in IBD. GDF15 and BMP2 add cytokine/growth factor context. SDC4 is a heparan sulfate proteoglycan that sequesters chemokines. The module is significantly upregulated in CD inflammation and reverses in remission, consistent with active endothelial inflammatory activation. This is the strongest and most coherent inflammatory module in the batch, representing the core NF-κB/chemokine response of activated endothelium. Neighbor M73 captures ECM remodeling and M72 captures upstream signaling, together forming a coordinated inflammatory endothelial program.
Genes
BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3, CXCL8, FHL2, GDF15, GNB5, HNRNPU, IRF8, LACTB, LRG1, NINJ1, REL, SDC4, SLC5A3, SOWAHC, TIPARP, TMSB4X
Most correlated modules
- Inflammatory Angiogenesis · correlation 0.81
- NF-κB Activation · correlation 0.77
- Inflammatory ECM Remodeling · correlation 0.74
- Integrated Stress Response · correlation 0.73
- Venous EC Identity · correlation 0.72
- Inflammatory EC Activation · correlation 0.64
- Actomyosin Contractility · correlation 0.64
- Hypoxia Stress Response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.