Type I Interferon
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 18 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 18 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical type I interferon-stimulated genes (ISGs): RSAD2 (Viperin), IFIT1/2/3/5, MX1/MX2, IFI44/IFI44L/IFI6, ISG15, OAS3, OASL, SAMD9, HELZ2, CMPK2, XAF1, IRF7 — this is a textbook type I IFN (IFN-alpha/beta) antiviral response signature. The module is coherent with nearly all genes showing core or strong membership. The lack of significant disease-state association (all deltas near zero and non-significant) contrasts with the neighboring M87 (IFN-gamma module), suggesting this type I IFN program is constitutively active at low levels or driven by viral/dsRNA sensing independent of IBD inflammation state. The co-expression neighborhood relationship with M87 is explained by shared JAK-STAT signaling downstream of both type I and type II interferons, causing partial overlap in ISG expression. All 18 genes are well-documented type I ISGs.
Genes
CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3, IFIT5, IRF7, ISG15, MX1, MX2, OAS3, OASL, RSAD2, SAMD9, XAF1
Most correlated modules
- Type I Interferon Response · correlation 0.82
- MHC Class I Presentation · correlation 0.64
- IFN-gamma Antigen Processing · correlation 0.63
- Arterial EC Homeostasis · correlation 0.51
- IFN-gamma Response · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.