MHC Class I Presentation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
The module is dominated by MHC class I genes: HLA-A, HLA-B, HLA-C, HLA-F, and B2M (beta-2-microglobulin, essential MHC-I component). BST2 (tetherin) and BTN3A1/A2 (butyrophilins) are interferon-stimulated antigen presentation regulators. IFI27L2 is an interferon-alpha-inducible gene. CYSTM1 is a stress-responsive gene. The module is downregulated in UC inflammation, possibly reflecting endothelial MHC-I expression that is modulated during active disease. This is a canonical MHC class I / antigen presentation module driven by interferon signaling. Neighbor context: directly neighbors M103 (ISG module) and M86 (IFN-gamma/antigen processing), forming a coherent interferon-MHC cluster.
Genes
B2M, BST2, BTN3A1, BTN3A2, CYSTM1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27L2
Most correlated modules
- Caveolae-mediated Transcytosis · correlation 0.76
- Type I Interferon Response · correlation 0.75
- Vascular EC Identity · correlation 0.71
- IFN-gamma Antigen Processing · correlation 0.69
- EC Quiescence Identity · correlation 0.69
- Endothelial Barrier Homeostasis · correlation 0.66
- NF-kB Chromatin Regulation · correlation 0.65
- Type I Interferon · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.