IFN-gamma Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 27 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 27 genes have a known function matching the annotation |
Why this annotation
The top hub genes are CXCL9, CXCL10, CXCL11 (IFN-gamma-induced chemokines), GBP1/2/4/5 (guanylate-binding proteins, canonical IFN-gamma effectors), TAP1 (antigen presentation, IFN-gamma target), SAMHD1, APOL6, TRIM22, PARP14, EPSTI1, IL18BP, IDO1, CASP1, and UBD — all well-established IFN-gamma-stimulated genes. This is a tight IFN-gamma response signature, distinct from the type I IFN module (M1) which is its topological neighbor. The strong upregulation in UC and CD inflammation (delta_inflammation_UC=0.875, delta_inflammation_CD=1.348) and reversal in UC remission (-1.247) is fully consistent with IFN-gamma-driven endothelial activation in IBD. The neighbor module M1 captures type I IFN (IFIT/MX/OAS genes), while M87 captures the IFN-gamma arm — both are interferon response programs but driven by distinct cytokines, explaining their co-expression network proximity. Concordant genes: CXCL9, CXCL11, GBP1, GBP5, CXCL10, SAMHD1, TAP1, APOL6, SECTM1, TRIM22, PARP14, IL18BP, GBP2, EPSTI1, GBP4, ISG20, UBD, CASP1, IDO1 (19 of 20 listed; APOL2 is weakly associated but APOL family members are IFN-gamma inducible).
Genes
APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11, CXCL9, EPSTI1, GBP1, GBP2, GBP4, GBP5, IDO1, IL15, IL15RA, IL18BP, ISG20, PARP14, PML, RIPK2, SAMHD1, SECTM1, TAP1, TRIM22, UBD
Most correlated modules
- IFN-gamma Antigen Processing · correlation 0.84
- Complement Innate Immune · correlation 0.68
- Type I Interferon Response · correlation 0.65
- MHC Class II Presentation · correlation 0.60
- Type I Interferon · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.