Lipid Droplet Hypoxia
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
PLIN2 (perilipin-2) is a lipid droplet-associated protein marking lipid accumulation. BNIP3 is a hypoxia-induced mitophagy/apoptosis regulator (HIF-1 target). CEMIP2 (TMEM2) is involved in hyaluronan catabolism and EC signaling. CNN3 (calponin-3) is a cytoskeletal/actin-binding protein. TSPAN4 is a tetraspanin involved in membrane organization. FCGRT (neonatal Fc receptor) mediates IgG transcytosis. FGD6 is a Rho GEF. The co-expression of PLIN2 and BNIP3 suggests a lipid-loaded hypoxic EC state, possibly reflecting lipid droplet accumulation under hypoxic/inflammatory stress. Modest upregulation in both UC and CD inflammation.
Genes
BNIP3, CEMIP2, CNN3, FCGRT, FGD6, PLIN2, SNTB2, TSPAN4
Most correlated modules
- Endothelial Quiescence Identity · correlation 0.75
- Inflammatory Stress Response · correlation 0.72
- Endothelial Cell Migration · correlation 0.67
- Venular Inflammatory Activation · correlation 0.66
- Quiescent Arterial EC · correlation 0.66
- Venous EC Identity · correlation 0.66
- Translation Elongation · correlation 0.64
- Vasoactive GPCR Signaling · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.