Translation Elongation
Gene co-expression module in Endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include EEF1A1 (elongation factor 1-alpha), EEF1B2 (elongation factor 1-beta), EEF2 (elongation factor 2), EIF3L, EIF3F, EIF4B (translation initiation factors), RACK1 (ribosome scaffold/translation), NACA (nascent polypeptide-associated complex), NPM1 (nucleophosmin, ribosome biogenesis), FBL (fibrillarin, rRNA methylation), NOP53 (ribosome biogenesis), HNRNPA1 (RNA-binding/splicing), PFDN5 (prefoldin, chaperone). This is a canonical translation/ribosome module with high mean expression and pct positive, no disease response — consistent with housekeeping translational machinery. Neighbor context: this module is distinct from the OxPhos module M67 but both are high-expression housekeeping programs, explaining their network proximity.
Genes
CCNI, COMMD6, EEF1A1, EEF1B2, EEF2, EIF3F, EIF3L, EIF4B, FBL, HNRNPA1, NACA, NOP53, NPM1, PFDN5, RACK1, SEC11A
Most correlated modules
- Oxidative Phosphorylation · correlation 0.87
- Angiogenic Metabolic Adaptation · correlation 0.85
- Inflammatory Stress Response · correlation 0.77
- Leukocyte Recruitment Signaling · correlation 0.71
- IL33 Alarmin Signaling · correlation 0.70
- Venular Inflammatory Activation · correlation 0.68
- Myeloid Contamination · correlation 0.68
- Venous EC Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.