Serotonergic receptor signaling
Gene co-expression module in Enterocytes
| Category | Secretion |
|---|---|
| Genes | 7 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
This is a small, mixed module. HTR4 (a serotonin receptor), KCNQ3 (a neuronal potassium channel), NECTIN3, LAMB1 and NFIB are more typical of neural or mesenchymal cells. However, expression is uniform with no dominant subset, so this is more likely a minor enterocyte signaling and adhesion program, possibly reflecting low-level ambient contamination. HTR4 can be expressed epithelially and regulates secretion.
Genes
HTR4, KCNQ3, LAMB1, LIMA1, NECTIN3, NFIB, TBC1D32
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.79
- Mitochondrial Energy Metabolism · correlation 0.69
- Long-gene nuclear transcripts · correlation 0.69
- YAP cytoskeletal remodeling · correlation 0.66
- Transit-amplifying progenitor · correlation 0.64
- ER chaperone/UPR · correlation 0.64
- Long-gene intronic signal · correlation 0.63
- Mature colonocyte metabolism · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.