Actin cytoskeleton
Gene co-expression module in Enterocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hubs are ACTB, ACTG1, MYL12B and JPT1, representing the actin cytoskeleton and actomyosin. CDC42EP5 regulates Cdc42-driven actin organization, CAST (calpastatin) protects the cytoskeleton, and CLDN7 and TMEM54 are epithelial junction/membrane genes. PIGR reflects colonocyte identity. Taken together this is an epithelial actin cytoskeleton/junctional program. Expression is uniform and high, so it may be partly housekeeping.
Genes
ACTB, ACTG1, CAST, CDC42EP5, CLDN7, JPT1, MYL12B, PIGR, TMEM54
Most correlated modules
- Core energy metabolism · correlation 0.81
- ER chaperone/UPR · correlation 0.78
- Abundant Transcript Baseline · correlation 0.73
- Respiratory Chain OXPHOS · correlation 0.66
- Electron Transport Chain · correlation 0.65
- IFN-gamma immunoproteasome · correlation 0.64
- Oxidative Phosphorylation · correlation 0.59
- High-abundance housekeeping · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.