SCUBA

PTPRB — Protein tyrosine phosphatase receptor type B

PTPRB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PTPRB's module in each cell type

Cell typeModuleShares the module with
EndothelialEC Quiescence Identity
Endothelial cell development		ABCC4, ARHGAP5, C1orf115, ENPP4, FAM107A, GIT2, IFNAR2, LRRFIP1 +8 moreView in SCUBA
EnterocytesJUN stress response
Stress		FOXO3, H1-2, H2AC6, JUN, LAMA3, LAMB3, ZNF292View in SCUBA
PericytesVascular Barrier Integrity
Migration & adhesion		C1orf115, FAM107A, GIMAP1, GIMAP4, GIMAP7, ITGB4, JAM2, MYCT1 +2 moreView in SCUBA

About the gene

SynonymsPTPB
Chromosome12: 70515870-70637440
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionHydrolase, Protein phosphatase
Biological processAngiogenesis

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.