STK24 — Serine/threonine kinase 24
STK24 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STK24's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | STAT3/JNK signaling Inflammation | CDC42SE2, ETV6, KIAA0232, LRRC1, MAPK8, PDLIM5, PELI1, STAT3 | View in SCUBA |
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, GNA12, LRRFIP2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K MAPK Signaling TCR Signaling | AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2 +11 more | |
| Smooth muscle cells | Cytoskeletal trafficking kinases Cytoskeletal | AMIGO2, CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3 +6 more | View in SCUBA |
About the gene
| Synonyms | MST-3, MST3, MST3B, STE20, STK3 |
|---|---|
| Chromosome | 13: 98445185-98577940 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis |
Function
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.