SKIL — SKI like proto-oncogene

SKIL belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SKIL's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Integrated Stress Response Stress	AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1 +4 more	View in SCUBA
CD4⁺ T cells	Unfolded Protein Response Protein processing & ER	ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3 +7 more	View in SCUBA
Endothelial	Inflammatory Stress Response Stress	CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1 +7 more	View in SCUBA
Enterocytes	Stress-responsive transcription Stress	AAK1, ABTB2, LPIN2, PLEC, RIGI, TMCC3	View in SCUBA
Goblet cells	Hypoxia Metabolic Stress Stress	ADGRE5, ANKRD37, ARL4A, FBXO32, IRS2, KLF2, LRRFIP1, TENT5A	View in SCUBA
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more	View in SCUBA
Lymphatic endothelial	Notch TGF-β Endothelial endothelial development	ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	TNF-driven Activation Inflammatory	ATP13A3, CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF +3 more	View in SCUBA
Mucosal-associated invariant T cell	ER Stress UPR Stress	DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA +9 more
Natural Killer cells	TGF-beta Repression DNA regulation & transcription	BZW1, GTF2B, HBP1, ODC1, POLR2K, SKP1, SPTY2D1, UBE2D3	View in SCUBA
Neutrophils	Neutrophil Adhesion Signaling Migration & adhesion	B3GNT5, ETS2, GK, ICAM1, LCP2, PDE4B, ZNF267
Pericytes	TGF-beta Negative Feedback Inflammatory	CTNND1, DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1 +6 more	View in SCUBA

About the gene

Synonyms	SNO, SnoA, SnoN
Chromosome	3: 170357342-170396835
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

May have regulatory role in cell division or differentiation in response to extracellular signals

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.