PKP4 — Plakophilin 4
PKP4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PKP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vasoactive GPCR Signaling Endothelial cell development | APLNR, BAIAP2L1, CALCRL, COPZ2, CYSLTR1, ETS2, FAM110D, FAM167B +10 more | View in SCUBA |
| Enterocytes | Cortical actin junctions Cytoskeletal | GOLGB1, JAK2, MYO1B, NEBL, STXBP5, TTC39B | View in SCUBA |
| Neutrophils | Myeloid Maturation Developmental | AFF2, CERS6, DGKG, FAF1, LRMDA, MSRB3, RSRC1 | |
| Pericytes | Pericyte Contractile Tone Cytoskeletal | CARD10, CARD8, EHD4, FAM110D, IL27RA, KANK3, LDB2, NOSTRIN +4 more | View in SCUBA |
About the gene
| Synonyms | p0071 |
|---|---|
| Chromosome | 2: 158456952-158682879 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.