YAP cytoskeletal remodeling
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
YAP1, together with the RhoGAP/GEF and actomyosin regulators ARHGAP26, FGD4, CDC42BPA, ABLIM1 and PIP5K1B, indicates cytoskeletal remodeling and mechanosensing. ITGB8 (a TGF-beta activator), SEMA3C and PTPRG fit a regenerative, migratory epithelial state, consistent with YAP-driven repair.
Genes
ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, FGD4, ITGB8, PDE4D, PIP5K1B, PTPRG, RREB1, SEMA3C, YAP1, ZBTB38
Most correlated modules
- Mature colonocyte metabolism · correlation 0.75
- Apicobasal polarity scaffold · correlation 0.67
- Serotonergic receptor signaling · correlation 0.66
- Focal adhesion actin · correlation 0.64
- Long-gene intronic signal · correlation 0.62
- Long-gene nuclear transcripts · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.