TOMM20 — Translocase of outer mitochondrial membrane 20
TOMM20 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOMM20's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ATP5MC3, COX5A, COX7B, GAPDH, LDHB, MDH2, NDUFA6, SLC25A3 | View in SCUBA |
| Gamma-delta T cells | Stress Epigenetic Silencing DNA/chromatin regulation | ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, NEU1, OTUD4, PHF1 +8 more | |
| Goblet cells | mRNA Translation Initiation RNA processing & translation | EEF1A1, EEF1B2, EIF3D, EIF3E, EIF3F, EIF3L, PABPC1, RACK1 +2 more | View in SCUBA |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1 +14 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more |
About the gene
| Synonyms | KIAA0016, MAS20, MOM19, TOM20 |
|---|---|
| Chromosome | 1: 235109341-235128837 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted membrane proteins |
| Biological process | Protein transport, Transport |
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.