NDUFA6 — NADH:ubiquinone oxidoreductase subunit A6
NDUFA6 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDUFA6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B +9 more | View in SCUBA |
| Fibroblasts | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ATP5MC3, COX5A, COX7B, GAPDH, LDHB, MDH2, SLC25A3, TOMM20 | View in SCUBA |
| Gamma-delta T cells | snRNP Splicing RNA processing & translation | CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more | |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
| Smooth muscle cells | mRNA Splicing Factors RNA processing & translation | ATF4, BEX3, CLIC4, COX20, HNRNPA0, NAP1L1, NME4, PCBP1 +7 more | View in SCUBA |
About the gene
| Synonyms | B14, CI-B14, LYRM6, NADHB14 |
|---|---|
| Chromosome | 22: 42085526-42090884 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.