TSPAN15 — Tetraspanin 15
TSPAN15 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSPAN15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Fibroblasts | BMP-Wnt Niche Signaling Developmental | CHMP4C, DCAF12L1, DIRAS1, DPEP2, GIPC3, ITGA9, LUZP2, MSTN +8 more | View in SCUBA |
| Glial cells | Oxidative Stress Response Stress | CAP1, CD59, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NDUFA11 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | IL-12 Cytotoxic Effector cytotoxicity | ANKZF1, ATP8B2, CD84, CTSH, DIP2A, HERC2, IL12RB1, LPCAT4 +7 more | |
| Pericytes | Basement Membrane Remodeling ECM remodeling | ADA, C4orf48, CYBA, DKK3, EFEMP2, G0S2, ISG20, LAMB3 +2 more | View in SCUBA |
| Smooth muscle cells | Neural Adhesion Program Development | CHL1, CNTN4, DSEL, EMID1, F3, IGFBP3, MATN2, SSC5D +1 more | View in SCUBA |
About the gene
| Synonyms | NET-7, TM4SF15 |
|---|---|
| Chromosome | 10: 69451465-69507666 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.