SSPN — Sarcospan
SSPN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SSPN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | IgA plasma cell B cell maturation | AIM2, CD27, CORO1B, IGHA1, IGHA2, JCHAIN, MGAT4A, OSBPL10 +2 more | View in SCUBA |
| Fibroblasts | Homeostatic Stromal Identity ECM production | ADAMTSL1, ADAMTSL3, EPB41L2, KAZALD1, LRIG1, NFIB, NUPR1, PDE5A +4 more | View in SCUBA |
| Glial cells | Lysosomal Sphingolipid Metabolism Housekeeping | ASAH1, BEX4, CLIC4, EID1, LAMP1, PSAP, SERPINB6, SGCE | View in SCUBA |
| Smooth muscle cells | Cytoskeletal Scaffolding Cytoskeletal | AKAP6, C3orf70, CNST, CTTNBP2, DACT3, IQGAP1, KIF13A, KLHL23 +8 more | View in SCUBA |
About the gene
| Synonyms | KRAG, SPN1, SPN2 |
|---|---|
| Chromosome | 12: 26121991-26299290 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.