Rho-ROCK Contractility
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
ROCK1 and ROCK2 are the top hub genes and are canonical Rho-kinase effectors that regulate actin cytoskeleton organization, stress fiber formation, and cell contractility. PPP1CB (myosin phosphatase regulatory subunit), ANXA6 (membrane-cytoskeletal linker), and ATP2B4 (calcium pump regulating cytoskeletal calcium dynamics) all support a cytoskeletal contractility program. GNG12 (G-protein signaling upstream of Rho/ROCK) and DYNLT3 (dynein motor component) further support cytoskeletal function. The module is moderately expressed (23.9%) and uniform across fibroblast subsets, consistent with a broadly active cytoskeletal maintenance program.
Genes
ANXA6, ATP2B4, CBX6, CSDE1, DYNLT3, GNG12, ITM2C, PPP1CB, ROCK1, ROCK2
Most correlated modules
- Actin-Integrin Adhesion · correlation 0.92
- Focal Adhesion ECM · correlation 0.90
- Notch Fibroblast Activation · correlation 0.87
- Myofibroblast Contractile · correlation 0.84
- Lysosomal Cytoskeletal · correlation 0.83
- Caveolae Mechanosensing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.