PCSK6 — Proprotein convertase subtilisin/kexin type 6
PCSK6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCSK6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ECM Glycan Remodeling ECM remodeling | ATP1B1, CHST11, COL8A2, LIMCH1, MGAT4A, MGAT5, MMP11, MYO7A +3 more | View in SCUBA |
| Lymphatic endothelial | ECM-driven Migration migration & adhesion | FMNL2, GLIS3, LAMC1, MAML2, RAPH1, SGIP1, ST3GAL6, STK32B +2 more | View in SCUBA |
About the gene
| Synonyms | PACE4, SPC4 |
|---|---|
| Chromosome | 15: 101289784-101525202 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.