RSPO3 — R-spondin 3
RSPO3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RSPO3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2 +6 more | View in SCUBA |
| Fibroblasts | Wnt-niche Fibroblast Developmental | ALDH1A1, APCDD1L, CAPN6, CCDC80, EBF1, FGL2, IGF1, MEOX2 +5 more | View in SCUBA |
| Smooth muscle cells | BMP-antagonist Niche Development | AP1S2, ARL4C, C3, CCBE1, CD74, CHRDL1, CISD1, GREM1 +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ14440, THSD2 |
|---|---|
| Chromosome | 6: 127118671-127199481 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Heparin-binding |
| Biological process | Sensory transduction, Wnt signaling pathway |
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non- canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.