Type I Interferon
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
IRF7 (master regulator of type I IFN), IRF8 (type I IFN and innate immune TF), and IRF9 (ISGF3 component for IFN-α/β signaling) are the defining hub genes of type I interferon signaling. ZC3HAV1 (ZAP/PARP13, antiviral RNA sensor that restricts viral replication) and HELZ2 (antiviral RNA helicase, ISG) are canonical interferon-stimulated genes with antiviral function. MYLIP (IDOL) has roles in innate immune lipid metabolism. NEU1 (sialidase) and ABHD5 are metabolic enzymes with immune-linked regulation. ICAM4 is an adhesion molecule. LACTB is a mitochondrial protein. IQCN is less characterized. The IRF7/IRF8/IRF9 + ZC3HAV1 + HELZ2 core strongly defines a type I interferon / antiviral innate immune program in intestinal fibroblasts.
Genes
ABHD5, HELZ2, ICAM4, IQCN, IRF7, IRF8, IRF9, LACTB, MYLIP, NEU1, ZC3HAV1
Most correlated modules
- Heat Shock Response · correlation 0.85
- NF-κB Immediate Early · correlation 0.83
- Fibroblast Quiescence · correlation 0.82
- Proteotoxic Stress Survival · correlation 0.81
- Co-transcriptional RNA Processing · correlation 0.80
- Chromatin Transcriptional Regulation · correlation 0.78
- Unfolded Protein Response · correlation 0.75
- Integrated Stress Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.