NXF1 — Nuclear RNA export factor 1
NXF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NXF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Chromatin Transcriptional Regulation Developmental | BRD2, C6orf62, CBX4, GLS, KLHL15, LSMEM1, MKNK2, NUFIP2 +4 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more | |
| Macrophages | Splicing Factor Regulation Housekeeping | ARAP1, CCNL1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Co-transcriptional Splicing RNA processing & translation | C9orf78, CCDC85C, CCNK, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5 +16 more |
About the gene
| Synonyms | DKFZp667O0311, Mex67, TAP |
|---|---|
| Chromosome | 11: 62792123-62806302 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | RNA-binding |
| Biological process | Host-virus interaction, mRNA transport, Protein transport, Translocation, Transport |
Function
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.