PDE1A — Phosphodiesterase 1A
PDE1A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | ADIRF, CHCHD10, DACH1, FXYD6, IGFBP3, KHDRBS3, LSP1, NDRG2 +3 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | ASAP2, DDX24, MYCBP2, NBDY, RBM24, RNF180, RRAS, RYR2 +3 more | View in SCUBA |
About the gene
| Chromosome | 2: 182139968-182523359 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding, Hydrolase |
Function
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.