PITX1 — Paired like homeodomain 1
PITX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PITX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | ADIRF, CHCHD10, DACH1, FXYD6, IGFBP3, KHDRBS3, LSP1, NDRG2 +3 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, APOC1, CLMP, CMIP, EDNRB, HSD17B6, IRS1, LTBP3 +8 more | View in SCUBA |
About the gene
| Synonyms | BFT, POTX, PTX1 |
|---|---|
| Chromosome | 5: 135027734-135034813 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.