ER Antigen Processing
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes CANX (calnexin), ERAP1 (ER aminopeptidase for MHC-I peptide trimming), SEC24C (COPII vesicle budding from ER), ATL3 (ER tubule morphology), PRKCSH (ER glucosidase II beta subunit), PDIA3/PRKCSH-related chaperones, and OS9-like quality control. Together with DCTN1 (dynactin for vesicle transport), this module represents ER protein folding, N-glycosylation quality control, and antigen processing. Neighbor M76 confirms an ER theme in this network neighborhood.
Genes
ACLY, ATL3, ATR, CANX, DCTN1, DDB1, ERAP1, FOXJ3, ITCH, LCP1, MSN, PRKCSH, PRRC2A, SEC24C, SND1, SPTAN1, UBAP2L, UBTF
Most correlated modules
- Vesicular Trafficking · correlation 0.90
- Interferon Stimulated Genes · correlation 0.86
- Chromatin Remodeling · correlation 0.86
- Chromatin Epigenetic Regulation · correlation 0.86
- T Cell Identity Program · correlation 0.84
- mTOR-Exocyst Signaling · correlation 0.84
- TCR Activation Signaling · correlation 0.82
- Hippo Pathway Signaling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.